Abstract
A new diterpenoid with an unusual capnosane skeleton, sinuhumilol A (1), alone with twelve known diverse compounds (2–13), were isolated from the South China Sea soft coral Sinularia humilis. Their structures and stereochemistry were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and/or by the comparison of the spectroscopic data with those reported in the literature. In bioassay, compound 11 exhibited interesting specific cytotoxicity against the human colon adenocarcinoma cell line HT-29 with IC50 value of 12.5 µM.
Graphical Abstract
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Supplementary materials
The following are available online at http://xx, Figures S1–S10: 2D NMR correlations, 1D, 2D NMR, HR-ESI-MS, and IR spectra of compound 1. Tables S1–S4: experimental and calculated NMR data, and values from DP4+ methods. Figure S11: correlation plots from DP4+ methods.
Disclosure statement
No potential conflict of interest was reported by the authors.