Cosmosporasides F–H, three new sugar alcohol conjugated acyclic sesquiterpenes from a Fusarium oxysporum fungus

Abstract

Three new sugar alcohol conjugated acyclic sesquiterpenes, cosmosporasides F–H (1–3), were isolated from the fermented cultures of Fusarium oxysporum SC0002. Their structures were elucidated by extensive analysis of spectroscopic data, including ¹H−¹³C long-range coupling constants (J_C,H). Their antibacterial, cytotoxic and anti-inflammatory activities were evaluated.

Graphical Abstract

Keywords:

• Cosmosporasides
• sugar alcohol conjugated sesquiterpenes
• Fusarium oxysporum
• secondary metabolites

Acknowledgments

We thank Prof. Tai-Hui Li from Guangdong Institute of Microbiology, for the microbilogical authentication, and also thank Ai-Jun Sun and Yun Zhang from South China Sea Institute of Oceanology, Chinese Academy of Sciences, for the measurement of HRESIMS.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by National Natural Science Foundation of China grant (No. 81172942).