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Abstract
Two new sesquiterpenes, named selina-4(14),7,11-trien-9-ol (1) and selina-4(14),11-dien-7-ol (2), along with two known compounds were isolated from rhizomes of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by TDDFT-ECD calculations. Compound 1 was found to moderately inhibit LSD1 activity with IC50 value of 34.0 μM. Compounds 1 and 4 exhibited a regulate effect on Keap1-Nrf2-ARE pathway.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the National Key Research and Development Program of China (2020YFE0201800), the Scientific and Technological Project of Science and Technology Department of Henan Province (202102310183 and 202102310173), the Key Scientific Research Project Plan of Henan Higher Education Institutions (19A360002), the Special Research Project of Henan Province on Traditional Chinese Medicine (2018ZYZD12), and the National Natural Science Foundation of China (82004019).