Brandisianones F and G from Millettia brandisiana Kurz and their cytotoxicity

Abstract

A new flavanone and a new chalcone, brandisianones F and G, were purified from the roots of Millettia brandisiana Kurz, moreover, sixteen known compounds were found. The chemical structures of all isolated compounds were identified using spectroscopic methods including 1D-NMR, 2D-NMR, MS, IR and CD data. Chalcone 15 exhibited the most cytotoxic activity against liver cancer, HepG2, and cholangiocarcinoma, KKU-M156, cell lines with IC₅₀ values of 1.74 ± 0.91 and 1.95 ± 0.95 µg/mL, respectively. Chalcones 2, 14, 16 and 18 as well as flavones 5, 6 and 12 showed moderate cytotoxicity with IC₅₀ values ranging from 5.39 to 14.00 µg/mL.

Keywords:

• Millettia brandisiana
• chalcones
• flavonoids
• KKU-M156 cells
• HepG2 cells

Acknowledgements

We thank the Thailand Research Fund and Khon Kaen University (RSA6280050) for financial support. We are indebted to The Center of Excellence for Innovation in Chemistry, Ministry of Higher Education, Science, Research and Innovation (Implementation Unit, Khon Kaen), Thailand. Financial support for Supakorn Arthan from the Scholarships for Human Resource Development of Sakon Nakhon Rajabhat University, Thailand is acknowledged.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was partially supported by the Thailand Research Fund and Khon Kaen University [RSA6280050].