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Abstract
Four new polyacetylene substances, sadivaethynes A–D, were isolated from the ethanol extract of the roots of Saposhnikovia divaricata (Turcz.) Schischk using repeated column chromatography. Structural elucidation of compounds 1–4 was established by 1D and 2D NMR spectra referring to the literature, together with high-resolution mass spectrometric analysis. All compounds were evaluated for cytotoxicity against two human cancer cell lines (MGC-803, Ishikawa) in vitro.
Graphical abstract
Author contributions
Yan Sun and Yan-Ping Sun have contributed equally to this work.
Conflict of interest
The authors have declared no conflict of interest.
Additional information
Funding
This work was financially supported by National Key Research and Development Project (2018YFC1707100), Heilongjiang university of Chinese medicine Founds (2018pt01, 2018bs03 and 2019ms37), College Youth Innovation Talent Training Project of Heilongjiang Province (UNPYSCT-2016206）.