Sigesbeckia K and L, two new diterpenoids from Sigesbeckia glabrescens with anti-inflammatory activity

Abstract

A chemical investigation of Sigesbeckia glabrescens Makino identified four compounds. On the basis of spectroscopic data, they were determined to be ent-pimarane-type diterpenoids and their analogues, among which were two previously undescribed compounds, Sigesbeckia K (1) and Sigesbeckia L (2). The anti-inflammatory effects of these compounds were evaluated by testing their inhibition of LPS-induced NO production in BV2 microglial cells, which revealed potential inhibitory effects with IC₅₀ value at 62.56 μM and compared with the positive control minocycline (IC₅₀ 32.84 μM).

Keywords:

• Sigesbeckia glabrescens Makino
• ent-pimarane-type
• diterpenoids
• anti-inflammatory

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Key R&D Program of China [grant number 2017YFC1701200], the National Natural Science Foundation of China [grant number 81374061], [grant number 81903789] and the China Postdoctoral Science Foundation [grant number 2020M670675].