Stachybotranes A–D, phenylspirodrimanes from the wetland fungus Stachybotrys chartarum with cytotoxic activities

Abstract

Four new phenylspirodrimanes, stachybotranes A–D (1–4), along with seven known analogues (5–11), were isolated from the extract of a wetland fungal strain Stachybotrys chartarum DTH12-9. The structures of new compounds were determined by spectroscopic analyses, X-ray crystallographic analysis, and the CD analysis of the in situ formed [Rh₂(OCOCF₃)₄] complex. Compounds 1-3, 5-8, and 10 were evaluated for in vitro cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480. Compounds 1, 2, and 7 exhibited moderate cytotoxic potency against various human cancer cell lines.

Graphical Abstract

Keywords:

• Stachybotrys chartarum
• wetland fungus
• phenylspirodrimanes
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by National science and technology Major projects of China (2017ZX09301036)