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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 10
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Research Articles

Two new cytotoxic cycloartane triterpenoids from Aphanamixis polystachya (Wall.) R. N. Parker

Yi-ting Wanga State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China;b Department of Chemical Science and Engineering, Yunnan University, Kunming, P.R. ChinaView further author information
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Shi-rui Fana State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China;b Department of Chemical Science and Engineering, Yunnan University, Kunming, P.R. ChinaView further author information
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Jie-yun Caia State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China;c Yunnan Tobacco Quality Supervision and Test Station, Kunming, P.R. ChinaView further author information
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Jing-jing Guoa State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaView further author information
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Xin-fang Zhanga State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China;b Department of Chemical Science and Engineering, Yunnan University, Kunming, P.R. ChinaView further author information
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Bi-juan Yanga State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaView further author information
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Xiao-jiang Haoa State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaCorrespondence[email protected]
View further author information
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Duo-zhi Chena State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. ChinaCorrespondence[email protected]
View further author information
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Pages 2473-2478 | Received 09 Oct 2020, Accepted 17 Mar 2021, Published online: 08 Jun 2021
 
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Abstract

Two new cycloartane triterpenoids, (24 R)-cycloartane-3β,24,25,30-tetrol (1) and (24 R)-24,25,30-trihydroxy-9,19-cycloartane-3-one (2), along with three known compounds (3-5) were isolated from leaves and twigs of Aphanamixis polystachya. The new compounds were elucidated based on comprehensive spectroscopic analysis, including 1 D, 2 D NMR and HREIMS. The in vitro cytotoxic activities evaluation of five human cancer cell lines revealed that compound 1 exhibited cytotoxic activity on all of tested human cancer cell lines, while compound 2 only had specific activity on SMMC-7721 cell line.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [grant numbers 81773610 and 81973212], Central Asian Drug Discovery and Development Centre of Chinese Academy of Sciences [grant number CAM201702].

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