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Abstract
Nine non-alkaloid constituents viz., sitostenone (1), β-sitosterol (2), naringenin (3), aromadendrin (4), matairesinol (5), vanillic acid (6), ferulic acid (7), protocatechuic acid (8) and sitosterol-3-O-β-D-glucopyranoside (9) were isolated from the acetone extract as well as five alkaloids viz., japindine (10), sarcorucinine D (11), dictyophlebin (12), chonemorphine (13) and N-formylchonemorphine (14) were isolated from the ethanol extract of Chonemorpha fragrans roots. Except β-sitosterol, all other non-alkaloid compounds and the alkaloid sarcorucinine D are being reported for the first time from C. fragrans. From the MIC and MBC values, it has been found that sarcorucinine D shows most promising antibacterial activity. Quantification of antibacterial activity as well as killing curve determinations were performed in order to confirm the efficacy of the compound. The cytotoxic activity studies revealed that it is nontoxic up to 100 µM concentration.
Graphical Abstract
Acknowledgements
SRD thanks CSIR for research fellowship. The authors thank the CSIR 12th 5-year plan project ‘NaPAHA’ for financial support. Ms. Saumini Mathew and Ms. S. Viji of CSIR-NIIST are acknowledged for recording the NMR and Mass spectra.
Disclosure statement
No conflict of interest was reported by the authors.
Supplementary material
Detailed experimental methods and spectral details are given in the supplementary material.