A new triterpenoid from the stems of Kadsura coccinea with antiproliferative activity

Abstract

A series of schiartane C₂₉ nortriterpenoids with 5/5/7/6/5 membered consecutive rings (1‒5) with an unique schinortriterpenoid skeleton including a new, kadcoccilactone V (1), together with four known ones (2‒5) and three known triterpenoids (6‒8) were identified from stems of Kadsura coccinea (Lem.) A. C. Smith. The structures of 1 and known compounds were elucidated by interpretation of 1D and 2D NMR, and HR-ESI-MS data as well as comparing those data in the literature. All the isolated compounds were examined for cytotoxic effects against six human cancer cell lines [(HCT-15 (colon), NUGC-3 (stomach), NCI-H23 (lung), ACHN (renal), PC-3 (prostate), and MDA-MB-231 (breast)]. Among them, compound 6 showed potent cytotoxicity against NCI-H23 (GI₅₀ 1.28 µM) and NUGC-3 (GI₅₀ 1.28 µM), and significantly inhibited on PC-3, MDA-MB-231, ACHN, HCT-15 with GI₅₀ values around 2.33 to 2.67 µM.

Graphical Abstract

Keywords:

• Kadsura coccinea
• Schisandraceae
• triterpene
• human cancer cells
• antiproliferative activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was supported by a grant from National Foundation for Science and Technological Development (no. NAFOSTED 104.01-2019.318) and partial supported by grant from Hanoi University of Science and Technology (no. T2020-PC-053).