Monascuslactams A–D, cytotoxic γ-lactams from marine fungus Monascus albidus BB3

Abstract

Amino acid-directed strategy becomes an efficient way to explore the alkaloids’ biosynthetic potential of marine fungi. The metabolites of marine fungus Monascus albidus BB3 were regulated obviously when cultured in GPY medium supplemented with L-tryptophan, L-phenylalanine, D,L-methionine, L-threonine, L-lysine, L-serine and L-valine. Four new γ-lactams, monascuslactams A–D (1–4), together with two known compounds pulchellalactam (5) and O-acetylperlolyrine (6) were obtained. Their structures were determined by comprehensive analysis on the 1 D and 2 D NMR, HRESIMS, UV and IR data, and their absolute configurations were assigned by the experimental and calculated ECD data analysis. Compounds 3, 4 and 6 showed moderate cytotoxicity against human cancer cell lines SUNE1, HepG2, QGY7701, GLC82, HCT116 and MDA-MB-231.

Graphical Abstract

Keywords:

• Marine fungus
• Monascus albidus
• γ-lactam
• monascuslactam
• amino acid-directed strategy

Disclosure statement

The authors declare no competing financial interest.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This research was funded by the National Science Foundation of China (No. 81872795), the Key Research and Development Program of Guangdong Province (No. 2020B1111110003), the Natural Science Foundation of Guangdong Province (No. 2018A030313157), and the Guangdong Provincial Science and Technology Research Program (Nos. 2019B070702003 and 2016A020222004).