https://orcid.org/0000-0002-6456-6543
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Abstract
Two new hasubanan alkaloids, stephalonester A (1) and stephalonester B (2), together with four known compounds, stephalonine E (3), longanone (4), cephatonine (5), and prostephabyssine (6) were isolated from the whole plant of Stephania longa. Their structures were determined by HR-ESI-MS, 1 D and 2 D NMR, ECD calculations, as well as by comparison with literature values. All compounds were evaluated for their anti-inflammatory activity in vitro. Compounds 4, 5, and 6 exhibited significantly inhibitory effects on TNF-α and IL-6 production with IC50 values range from 6.54 to 30.44 µM.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This research was supported by the National Natural Science Fund of China under grant [number 81570202]; the Guangdong Basic and Applied Basic Research Fund Project under grant [number 2019A1515110696]; the Key Platform and Scientific Research Project of Guangdong Provincial Education Department [number 2018KTSCX246]; and the University Youth Innovative Talents Research Program of the Department of Education of Guangdong Province under grant [number 2019KQNCX171].