Phytoprostane and phenolic compounds from Chromolaena palmaris

Abstract

The chemical investigation of Chromolaena palmaris (Sch.Bip. ex Baker) R.M. King & H. Rob. expands the phytochemical composition knowledge of Chromolaena genus, since this is the first chemical investigation of this species. Twenty-five compounds were identified, including a phytoprostane, 17 flavonoids, 6 phenolic acids, and a caffeoyl-glucoside derivative obtained by classical chromatography and UHPLC-HRMS/MS analysis. Moreover, anti-Mycobacterium tuberculosis and antiproliferative activities of C. palmaris were evaluated. Dichloromethane fraction showed cytotoxicity towards human cancer cell lines, presenting TGI values on glioma (U251) of 27.8 μg mL⁻¹. Furthermore, compounds 1 and 2 exhibited antimicrobial activity against Mycobacterium tuberculosis with MIC of 62.5 and 15.6 μg mL⁻¹, respectively.

GRAPHICAL ABSTRACT

Keywords:

• Chromolaena palmaris
• Asteraceae
• phytoprostanes
• flavonoids
• antiproliferative activity
• antitubercular activity

Disclosure statement

The authors declare that there are no conflicts of interest.

Additional information

Funding

We are grateful to CNPq for fellowship (301269/2017-3), and CAPES. This study was funded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES), Finance Code 001, and INCTBioNat (CNPq 465637/2014-0). The authors A.L.T.G.R. and M.A.F. thank CNPq for research productivity fellowship.