https://orcid.org/0000-0002-8831-7154
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Abstract
Five tigliane (1−5) and one ingenane (6) diterpenoids were isolated from the ethanol extract of Euphorbia tirucalli. The structures of these compounds were identified based on analysis of their spectroscopic data. Among them, compound 12-O-(2E,4E,6E,8E-tetradecatetraenoyl)-13-O-isobutyroyl-4β-deoxyphorbol (1) was a new tigliane. The Rho123 effluxion assay showed that tiglianes with a trans-fused 5/7 ring system such as compounds 1, 2, and 4 had potent inhibitory activity against P-glycoprotein in HepG2/ADR cells.
GRAPHICAL ABSTRACT
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No potential conflict of interest was reported by the authors.
Additional information
Funding
The authors acknowledge the financial support from the National Natural Science Foundation of China [number 81973195], [number 81973203], the Fundamental Research Funds for the Central Universities [number 20ykjc04], [number 17ykzd12], and the Key-Area Research and Development Program of Guangdong Province, China [number 2020B1111110003].