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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 12
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Research Articles

Glycosides from Buddleja officinalis with their protective effects on photoreceptor cells in light-damaged mouse retinas

Zehai Longa School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
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Xiaoye Dub Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;c Clinical Research Institute of Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaView further author information
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Qiyao Wanga School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
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Zhijian Xud CAS Key Laboratory of Receptor Research; Drug Discovery and Design Centre, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaORCID Iconhttps://orcid.org/0000-0002-3063-8473View further author information
ORCID Icon,
Bo Lid CAS Key Laboratory of Receptor Research; Drug Discovery and Design Centre, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China;e University of Chinese Academy of Sciences, Beijing, ChinaView further author information
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Yong Zhangd CAS Key Laboratory of Receptor Research; Drug Discovery and Design Centre, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China;e University of Chinese Academy of Sciences, Beijing, ChinaCorrespondence[email protected]
View further author information
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Yu Chenb Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;c Clinical Research Institute of Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China;f Laboratory of Clinical and Molecular Pharmacology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
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Qi Jiaa School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCorrespondence[email protected]
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Yiming Lia School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaView further author information
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Weiliang Zhud CAS Key Laboratory of Receptor Research; Drug Discovery and Design Centre, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China;e University of Chinese Academy of Sciences, Beijing, ChinaView further author information
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Pages 3022-3030 | Received 19 Apr 2021, Accepted 08 Jun 2021, Published online: 26 Jun 2021
 
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Abstract

A new phenylethanoid, hebitol IV (1), along with fifteen known glycosides (2-16), were isolated from water extract of the flower buds of Buddleja officinalis. Their structures were elucidated on the basis of 1 D-NMR, 2 D-NMR and MS data. Molecular docking showed the potential activities of the natural products against VEGFR-2. Bioassay results revealed that the compounds 10 and 14 exhibited strong inhibitory activity against VEGFR-2 with IC50 values of 0.51 and 0.32 μM, respectively. Moreover, the potential retinal protective effects of 10 and 14 were then investigated in the mouse model featuring bright light-induced retinal degeneration. The results demonstrated remarkable photoreceptor protective activities of 10 and 14 in vivo.

Graphical abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Natural Science Foundation of China (81603270, YZ; 81673790, YC), the Shanghai Sailing Program (16YF1414100), which are gratefully acknowledged.

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