LC-ESI/MS-phytochemical profiling with antioxidant and antiacetylcholinesterase activities of Algerian Senecio angulatus L.f. extracts

Abstract

Senecio angulatus L.f. is a flowering plant from the Asteraceae family that is native to South Africa and which was observed recently in the north and the east of Algeria. This study was aimed for the first time, to evaluate concomitantly phytochemical profiles, using LC-ESI/MS analysis, following by testing and assessing in vitro antioxidant and antiacetylcholinesterase activities of these specific species. The results indicated that the hydromethanolic and the acetate extracts have shown remarkable potent inhibitory effects on AChE with IC₅₀ of (6.04 ± 0.05; 6.72 ± 0.10 µg/mL) respectively along with antioxidant potential of acetate for FRAP and phenanthroline methods with A_0.5 of (11.15 ± 0.72; 5.72 ± 0.13 µg/mL) successively. Moreover, a high amount of cynarin and trans-ferulic acid was found in this extract whilst butanolic extract has recorded the highest amount of chlorogenic acid. Indeed phenolic compounds usually have a hydroxyl in their structure which may contribute significantly to the antioxidant activity.

Graphical Abstract

Keywords:

• Senecio angulatus L.f.
• asteraceae
• LC-ESI-MS/MS
• antioxidant
• AChE
• phenolic
• compounds

Acknowledgment

The authors want to thank the MESRS Algeria (Ministère de l’Enseignement Supérieur et de la Recherche Scientifique), DGRSDT and CRBt Constantine for the financial support and Prof. Khellaf Rebbas (Msila University) for providing picture of plant.

Disclosure statement

No potential conflict of interest was reported by the authors.