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Natural Product Research
Formerly Natural Product Letters
Volume 37, 2023 - Issue 1
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A new cycloheptane derivative from the fungus Penicillium crustosum JT-8

Jun-Tao HuFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Kunming, P.R. ChinaView further author information
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Jia-Peng WangFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Kunming, P.R. ChinaORCID Iconhttps://orcid.org/0000-0002-1702-7029View further author information
ORCID Icon,
Yan ShuFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Kunming, P.R. ChinaView further author information
,
Xue-Yun CaiFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Kunming, P.R. ChinaView further author information
,
Cheng-Tong SunFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Kunming, P.R. ChinaView further author information
,
Hao DingFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Kunming, P.R. ChinaView further author information
,
Le CaiFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Kunming, P.R. ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0970-4920View further author information
ORCID Icon &
Zhong-Tao DingFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Kunming, P.R. ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7860-060XView further author information
ORCID Icon show all
Pages 141-149 | Received 06 Jan 2021, Accepted 22 Jun 2021, Published online: 09 Sep 2021
 
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Abstract

A new highly oxygenated cycloheptane derivative crustane (1), along with fourteen known compounds (2–15) were isolated from Penicillium crustosum JT-8. The structure of compound 1 was determined by extensive spectroscopic data, DP4+ probability analyses and dimolybdenum CD method. Compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus with MIC of 4.0 μg/mL.

Graphical Abstract

Acknowledgment

Thanks to Advanced Analysis and Measurement Center of Yunnan University for providing sample testing service.

Additional information

Funding

This work was financially supported by grants from the Natural Science Foundation of China (Nos. 81960760, 81860623), a grant from the Natural Science Foundation of the Yunnan Province ((No. 202001BB050042). Program for Changjiang Scholars and Innovative Research Team in University (IRT_17R94), a project of Yunling Scholars of Yunnan province and a Program for Excellent Young Talents. The Yunnan University’s Research Innovation Fund for Graduate Students. Authors thank Advanced Analysis and Measurement Center of Yunnan University for the sample testing service.

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