Three novel quinolinone alkaloids from the leaves of Melicope denhamii

Abstract

Three previously unreported quinolinone alkaloids: melicodenines J-L (1-3) and six known compounds (4-9), were isolated from the leaves of Melicope denhamii (Seem) T.G. Hartley. The structures of three quinolinone alkaloids were identified based on HRESIMS and NMR spectra. Compounds 1-9 were assayed in three cancer cells (MCF-7, HeLa, and P-388). Compounds 1 and 5 showed high cytotoxic activity against HeLa cells with IC₅₀ values of 1.8 and 0.8 µM, respectively.

Graphical Abstract

Keywords:

• Melicope denhamii
• melicodenines J-L
• quinolinone adduct
• cytotoxic

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research financially supported by Universitas Airlangga, Surabaya, Indonesia (Hibah Mandat 2019 by Tjitjik Srie Tjahjandarie).