Eupatorin 3′-O-glucopyranoside, a trimethoxyflavonoid glucoside from the aerial parts of Salvia mellifera

Abstract

Salvia mellifera, native to California, Baja California, and Mexico, is a medicinal herb traditionally used to relieve pain, body aches, including chronic pain. A detailed phytochemical investigation of aerial parts of S. mellifera was accomplished to find species-specific markers and to differentiate the closely related, often (un)intentionally substituted with S. apiana. A total of 22 metabolites, including flavonoids (1–14), triterpenoids (15–18), diterpenoids (19–21), and phenylpropanoid (22), were isolated and characterized thoroughly. Among the isolates, eupatorin 3′-O-glucopyranoside (1) was identified as undescribed phytochemical and detailed structure elucidation was achieved through extensive NMR and mass spectral data analysis.

Graphical Abstract

Keywords:

• Salvia mellifera
• black sage
• Lamiaceae
• aerial parts
• eupatorin 3′-O-glucopyranoside

Disclosure statement

The authors report no potential conflict of interest.

Additional information

Funding

This research is supported by the “Holistic Approach for Potential Drug Interactions with Botanical Drugs” funded by the Center for Drug Evaluation and Research, US Food and Drug Administration, grant number HHSF223201810175C.