Potential use of wood metabolites for cancer treatment

Abstract

The study of medicinal plants for cancer treatment has gained attention due to an increasing incidence of cancer worldwide and antineoplastics-related undesirable secondary effects. Most of the natural products of medicinal plants that have been evaluated for cytotoxic activity, are derived from leaves, bark, roots and flowers. However, natural products derived from wood have demonstrated a cytotoxic effect with promising results. Moreover, some fractions and compounds have been isolated of wood in order to increase the effect. This review presents in vitro experimental evidence of cytotoxic effect of natural products from wood against cancer cell lines. It also provides considerations and recommendations to obtain herbal medicines over time.

Graphical Abstract

Keywords:

• Wood extract
• phenolic compounds
• cytotoxicity
• apoptosis
• cancer cell lines

Disclosure statement

No potential conflict of interest was reported by the authors.