Five new quinoline alkaloids from Sauropus hirsutus Beille and their cytotoxicity

Abstract

Chemical investigation of the whole plant of Sauropus hirsutus Beille led to the isolation of eight quinolines and two known flavonoids. Furthermore, five quinolines were new, two were reported in plant for the first time and one was known. Cytotoxicity evaluation against cholangiocarcinoma, KKU-M156, showed that the most active compound was 4-hydroxy-6-methoxy-7,8-methylenedioxyquinaldine (IC₅₀ 20.54 ± 6.82 µM) which was a little more active than the cisplatin standard (IC₅₀ 24.39 ± 1.14 µM).

Graphical Abstract

Keywords:

• Sauropus hirsutus
• quinaldine
• HepG2 cells
• KKU-M156 cells

Acknowledgements

The Center of Excellence for Innovation in Chemistry, Ministry of Higher Education, Science, Research and Innovation (Implementation Unit, Khon Kaen) Thailand is gratefully acknowledged.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

We acknowledge the Thai Research Fund (RSA6280050) and Khon Kaen University for financial support. The Post-Doctoral Training Program from the Research Affairs and Graduate School, Khon Kaen University for T. Sribuhom is acknowledged (Grant no. 591471). This work was partially supported by the Thailand Research Fund and Khon Kaen University [RSA6280050].