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Natural Product Research
Formerly Natural Product Letters
Volume 37, 2023 - Issue 3
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Research Articles

Micropyrones A and B, two new α-pyrones from the actinomycete Microbacterium sp. GJ312 isolated from Glycyrrhiza uralensis Fisch

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Pages 462-467 | Received 29 Jun 2021, Accepted 01 Sep 2021, Published online: 21 Sep 2021
 

Abstract

Two new α-pyrones, micropyrones A (1) and B (2), along with four known γ-pyrones, nocapyrone D (3), nocapyrone A (4), marinactinone A (5), and nocapyrone H (6), were isolated from the culture extract of actinomycete Microbacterium sp. GJ312, which was isolated from Glycyrrhiza uralensis. The structures of these compounds were identified by analysis of spectral data. They are the first α- and γ-pyrones reported from the genus Microbacterium. The antibacterial activity of all compounds against Staphylococcus aureus and methicillin resistant S. aureus was evaluated. However, none of them showed significant activity. This study represents the first phytochemical example of a Glycyrrhiza-derived actinomycete.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was supported by Department of Science and Technology of Guangzhou (grant number 201904010134), the National Natural Science Foundation of China (grant number 31970376), and Youth Innovation Promotion Association CAS to Zhongyu Zhou (grant number 2016310).

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