One new constituent from the stem bark of Chrysophyllum lacourtianum De Wild. (sapotaceae)

Abstract

The phytochemical investigation of the methanol extract of the stem bark of Chrysophyllum lacourtianum led to the isolation and characterization of one new secondary metabolite, lacourtianal (1), together with eight known compounds. Compounds 2; 3; 5; 6; 7 and 9 were reported for the first time from Chrysophyllum genus. The structures of compounds 1–9 were elucidated on the basis of 1 D and 2 D NMR spectroscopic and mass spectrometric data as well as comparison with the literature. The antibacterial activity of the methanol extract, fractions and compounds 1–9 were evaluated against bacterial strains. The methanol extract exhibited moderate activity against Staphylococcus aureus NR4674 with MIC values of 500 µg/mL. The n-hexane fraction showed moderate activity against Staphylococcus aureus (ATCC 43300 and ATCC 25923) with MIC values of 125 µg/mL and ursolic acid (5) exhibited strong activity against Enterobacter aerogenes CPC and Escherichia coli ATCC 25322 with MIC values of 7.8 and 3.9 µg/mL respectively.

Graphical Abstract

Keywords:

• Lacourtianal
• Sapotaceae, Chrysophyllum lacourtianum
• antibacterial activity

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was supported by Yaoundé-Bielefeld Bilateral Graduate School Natural Products with Anti-parasite and Anti-bacterial Activity (YaBiNaPA) project, financially supported by Deutscher Akademischer Austauschdienst (DAAD) [grant number 57316173].