A new polyphenolic isoprenylated acetophenone dimer from the stem bark of Acronychia pedunculata (L.) Miq

Abstract

A new acetophenone dimer, 5′-prenylacrovestone (1), together with nineteen known compounds (2–20), were isolated from the stem bark of Acronychia pedunculata (L.) Miq. Their structures were identified by thorough analysis of spectroscopic (IR, 1D and 2D NMR) and mass spectrometric data. The isolated compounds were tested against the bacterial pathogens MRSA, B. cereus, S. aureus and E. coli. Compound 3 demonstrated exceptionally potent antibacterial activity against each of the four strains (MIC values of 1 µg/mL).

Graphical Abstract

Keywords:

• Acronychia pedunculata
• Rutaceae
• isoprenylated acetophenone
• antibacterial

Acknowledgments

SN thanks the Development and Promotion of Science and Technology Talents Project (DPST) for a scholarship.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Center of Excellence for Innovation in Chemistry (PERCH-CIC) and Khon Kaen University. This project was funded by the National Research Council of Thailand (NRCT) contract n° NRCT5-TRG63003-01.