Cytotoxic polyketides from the deep-sea-derived fungus Aspergillus fischeri FS452

Abstract

Six globoscin derivatives (1‒6) including two new ones fischerins A (1) and B (2) were isolated from the deep-sea-derived fungus Aspergillus fischeri FS452. Their structures were elucidated by comprehensive spectroscopic analysis and the absolute configurations were determined by the quantum chemical ECD calculations. The in vitro cytotoxicity assays indicated that fischerin B (2) exhibited potential activities against the four tested human cancer cell lines (SF-268, MCF-7, HepG-2 and A549) with the IC₅₀ values in the range of 7–10 µM.

Graphical Abstract

Keywords:

• Polyketides
• deep-sea-derived fungus
• quantum chemical calculations
• cytotoxicity

Acknowledgements

We gratefully acknowledge support from the Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences, and thank Ai-Jun Sun, Yun Zhang and Xuan Ma, South China Sea Institute of Oceanology, Chinese Academy of Sciences, for the measurement of HRESIMS.

Disclosure statement

The authors declare no competing financial interest.

Additional information

Funding

This work was supported financially by the National Natural Science Foundation of China (41906106, 31272087), The Natural Science Foundation of Guangdong Province, China (2021A1515011416), Guangdong Provincial Special Fund for Marine Economic Development Project (GDNRC [2020]042), the Team Project of the Natural Science Foundation of Guangdong Province (2016A030312014), the GDAS’ Project of Science and Technology Development (2019GDASYL-0103007)