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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 22
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Short Communications

α-zingiberene, a sesquiterpene from essential oil from leaves of Casearia sylvestris, suppresses inflammatory angiogenesis and stimulates collagen deposition in subcutaneous implants in mice

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Pages 5858-5862 | Received 09 Aug 2021, Accepted 06 Dec 2021, Published online: 27 Dec 2021
 

Abstract

α-zingiberene is a phytochemical of the sesquiterpenes class, the major constituent of the essential oil from the leaves of Casearia sylvestris, a plant widely used in traditional medicine for the treatment of inflammatory diseases, tumours, and bacterial infections. In the present study, we evaluated the effects of daily administration of α-zingiberene (0.01, 0.1 and 1 μg diluted in 10 μl of 0.5% DMSO) on the inflammatory, angiogenic, and fibrogenic components, induced by subcutaneous sponge implants in an animal model. Treatment with sesquiterpene resulted in a reduction in macrophage activation, as well as in mean blood vessels and in the activity of metalloproteinases 2 and 9. Furthermore, it resulted in an increase in collagen deposition near the implants. These results show the therapeutic potential of α-zingiberene in the treatment of pathologies, in which processes such as inflammation and angiogenesis are exacerbated, or even for the treatment of chronic wounds.

Graphical Abstract

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was supported by Conselho Nacional de Pesquisa/CNPq (446480/2014-2), Fundação de Amparo à Pesquisa de Minas Gerais/FAPEMIG (APQ-04436-10 and APQ-02238-14), and Instituto Nacional de Ciência e Tecnologia (INCT-NanoBiofar) – Brazil.

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