A new lignan from Pandanus tectorius

Abstract

A new lignan, named (8S, 8′S)-2,2',3,3'-tetramethoxy-4'-hydroxy-epoxylignan-4-O-β-D-glucoside (1), together with eight known compounds (2–9), was isolated from the leaves of P. tectorius. Their structures were elucidated on the basis of spectral characteristics and comparison with the data of literatures. Besides, the absolute configuration of 1 was established by using ECD calculations. The cytotoxicity of 1 in vitro against three selected tumor cell lines (A549, HeLa and MCF-7) was evaluated by MTT assay. The results showed that compound 1 exhibited moderate cytotoxicity against HeLa cell with IC₅₀ value of 19.30 ± 4.46 μM.

Graphical Abstract

Keywords:

• Pandanus tectorius
• lignan
• Pandanaceae
• antitumor

Disclosure statement

The authors declare no compete in financial interests.

Acknowledgements

This work was financially supported by Natural Science Foundation of JiangXi Province (No. 20192BAB205105), the Research Project of the Educational Department in JiangXi Province (GJJ190674), and the Doctoral Scientific Research Foundation of Jiangxi University of CM (2019WBZR004).

Supplementary data

Copies of spectra of compound 1.

Additional information

Funding

This work was financially supported by Natural Science Foundation of JiangXi Province (No. 20192BAB205105), the Research Project of the Educational Department in JiangXi Province (GJJ190674), and the Doctoral Scientific Research Foundation of Jiangxi University of CM (2019WBZR004).