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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 22
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Research Articles

Antioxidant effects of diarylheptanoids from two Curcuma species

, , , , & ORCID Icon
Pages 5732-5739 | Received 29 Sep 2021, Accepted 10 Dec 2021, Published online: 29 Dec 2021
 

Abstract

Five linear diarylheptanoids (1-5), including a new one (1), were isolated from the rhizomes of Curcuma kwangsiensis S. G. Lee et C. F. Liang, while four linear diarylheptanoids (6-9) and four cyclic diarylheptanoids (10-13) were isolated from the roots of Curcuma aromatica Salisb. Using the model of H2O2-induced PC12 cells, the antioxidant effects of these thirteen diarylheptanoids from these two traditional Chinese medicines from Curcuma genus of Zingiberaceae family were investigated. As result, they produced different efficiency on damaged cell viability, ROS, LDH, SOD, CAT, and GSH-Px, which were the six indexes related to oxidative stress. Further, the correlation between these six bio-indexes and 53 selected molecular descriptors of diarylheptanoids was determined by PLS regression analysis.

Graphical Abstract

Disclosure statement

No conflict of interest was reported by the authors.

Additional information

Funding

This research was funded by the Natural Science Foundation of China (32060105) and the Applied Basic Research Foundation of Yunnan Province (202101AT070133).

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