Abstract
Ziziphus jujuba Mill. is a deciduous shrub, belonging to the Rhamnaceae family. Phytochemical investigation of Z. jujuba seeds showed the presence of three undescribed 8,4′-type oxyneolignans (1-3). Their structures were elucidated by comprehensive spectroscopic analyses. All isolated compounds were tested for antitumor activity against two human hepatoma cells (Hep3B and HepG2) and exhibited moderate cytotoxicity (IC50: 33.79-49.62 µM).
Graphical Abstract
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Acknowledgments
The study was supported by Natural Science Foundation of Hunan Province, China (Grant No. 2018JJ3480); Research Foundation of the Education Bureau of Hunan Province, China (Grant No. 18B498); Scientific Research Foundation of the Hunan Provincial Health Commission, China (Grant No. 202102040901); Young Core Instructor Foundation from the Education Bureau of Hunan Province, China (Grant No. [2018] 574)
Disclosure statement
No conflict of interest was reported by the authors.