Arenga westerhoutii Griff.: bioactive constituents, nutraceuticals, antioxidant and anti-diabetic potential of stem extract and an insight into molecular docking analysis

Abstract

Herein, we reported a systematic scientific study of Arenga westerhoutii Griff. by evaluating its bioactive components, nutraceuticals, antioxidant and anti-diabetic properties. Three major bioactive compounds were identified using HPLC and HRMS. Quantification of the components through HPLC yielded the presence of 75.67 ± 0.05, 38.19 ± 0.10 and 13.11 ± 0.02 µg/mL of chlorogenic acid, ferulic acid and epicatechin respectively in 1 mg/ml of the extract. 50% MeOH hydro-alcoholic extract was found to show lowest IC₅₀ value in both in-vitro antioxidant (IC₅₀ = 2.925 ± 0.12 µg/mL, DPPH assay) and anti-diabetic assays (IC₅₀ = 18.03 ± 0.18 µg/mL, α-glucosidase assay). Further analysis by molecular docking study suggested the interaction of components towards α-glucosidase enzyme.

Graphical Abstract

Keywords:

• nutraceuticals
• chlorogenic acid
• ferulic acid
• epicatechin
• molecular docking

Acknowledgement

The authors thank Director CSIR-NEIST, Jorhat, Assam for providing facilities and valuable advice. We also thank to Kipa Kaman, Life Line Multi-purposes Co-operative Society Pvt Ltd for his help and support during study.

Additional information

Funding

The authors also thank to SEED Division, New Delhi (Grant No: SP/TSP/020/2017 & DST/SEED/TSP/STI/2020/266) for financial support.