Sterehirsutynes A − C: three new acetylenic aromatic metabolites from Stereum hirsutum

Abstract

Three new acetylenic aromatic compounds, sterehirsutynes A–C (1–3), along with three known congeners, frustulosinol (4), vibrayne (5), and sterehirsutinol (6), were isolated from the culture broth of Stereum hirsutum. Their structures were determined by detailed analyses of NMR and high-resolution mass. Chiral column analysis showed that compounds 2 and 3 were racemic mixtures. These new compounds were evaluated for porcine pancreatic lipase (PPL) inhibitory activities, and compounds 1 and (±) 3 showed moderate inhibitory activity against PPL, with IC₅₀ values of 23.2 ± 1.04 and 21.8 ± 2.15 μM, respectively.

Graphical Abstract

Keywords:

• Stereum hirsutum
• aromatic alkyne
• porcine pancreatic lipase activities

Disclosure statement

The authors declare no competing financial interest.

Additional information

Funding

This work was financially supported by the Program for Changjiang Scholars of Ministry of Education of the People's Republic of China (No. T2016088); the National Natural Science Foundation for Distinguished Young Scholars (81725021); the National Natural Science Foundation for Excellent Young Scholars (81922065); the National Science and Technology Project of China (2018ZX09201001-001-003); Innovative Research Groups of the National Natural Science Foundation of China (81721005); the Academic Frontier Youth Team of HUST (2017QYTD19); and the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST). We thank the Analytical and Testing Center at Huazhong University of Science and Technology for assistance in the acquisition of the ECD, UV, and IR spectra.