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Abstract
Two previously undescribed dihydrophenanthrene derivatives (1 and 2) were isolated along with twelve known analogues from the whole plant of Dendrobium terminale. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis. The NMR data of known phenanthrene derivatives (7 and 9) were revised by 2D NMR. The isolated compounds were evaluated for cytotoxicity against three kinds of tumor cell lines (sw1990, HCT-116, and HepG2). Especially compounds 11 and 14 showed stronger antitumor effects, and the structure-activity relationship of these compounds was discussed.
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Disclosure statement
No potential conflict of interest was reported by the authors.
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Funding
This work was financially supported by the National Natural Sciences Foundation of China (No. 82060706 and 31960204), the Science and Technology Department Foundation of Guizhou Province (No.QKHPTRC[2017]5733-052 and [2017]5733-049, No.QKHZC[2020]1Y402 and [2020]4Y211, QSKH2019003-005), and the State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medicial University (No. FAMP201902K); Science and Technology Department of Guizhou Province (QKHRCPT[2017]5101); Talent Team Project of Zunyi City (2020) No.10 (E-361); Zunyi Science and Technology Bureau, (ZunShiKeHe 2019-16); Honghuagang District Science and Technology Bureau of Zunyi (ZHKHSZ[2019]27).