Two new chromanone acids from the stem bark of Calophyllum peekelii Lauterb

Abstract

Three chromanone acids were isolated from the stem bark of Calophyllum peekelii Lauterb. Among them are two new chromanone acids, calopeekelioic acids A (1) and B (2), along with calolongic acid (3), Their structures were established by analyzing a combination of HRESIMS, 1 D, and 2 D NMR spectra. Chromanone acids 1-3 were evaluated for their antiplasmodial activity against Plasmodium falciparum strain 3D7. Compounds 1-2 showed high activity with an IC₅₀ value of 1.70 and 1.01 µg/mL, respectively.

Graphical abstract

Keywords:

• Calopeekelioic acids A-B
• chromanone acid
• Calophyllum peekelii
• antiplasmodial

Acknowledgments

The authors wish grateful to the Penelitian Dasar Program, Universitas Airlangga, Surabaya, Indonesia, 2021.

Disclosure statement

No potential conflict of interest was reported by the authors.

Figure 1. Structures of compounds 1-3 from C. peekelii.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.