Polymeric film containing pomegranate peel extract as a promising tool for the treatment of candidiasis

Abstract

Polymeric films containing pomegranate peel extract (PPE) can act as a drug-delivery platform for topical treatment of candidiasis. The composition, mechanical resistance, and in vitro antifungal activity of a polymeric film containing PPE at 1.25 mg.mL⁻¹ were investigated. Films were prepared using a solvent casting technique. The incorporation of PPE in the polymeric matrix gave rise to homogeneous, smooth, shiny, and yellowish-brown films. FTIR spectra of the film containing PPE showed differences without compromising the stability of the extract and the matrix. SEM analysis showed the existence of interruptions in the continuity of the films with extract, which promoted a reduction in the mechanical parameters without significantly changing the tensile strength and elongation at break. Films showed adequate mechanical properties and antifungal activity against Candida albicans, C. glabrata, C. krusei and C. tropicalis.

Graphical Abstract

Keywords:

• Punica granatum
• polymeric film
• antifungal activity
• Candida

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors are thankful to Fundação de Amparo à Pesquisa e Inovação do Espírito Santo – FAP ES (notice No. 18/2021; Project 201/2019) and notice No. 03/2021; Project 0427/2021); Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenaçáo de Aperfeiçoamento de Pessoal de Nível Superior (financing modality 001) and Laboratório de Ultraestrutura Celular Carlos Alberto Redins da UFES - edital MCT/FINEP/CT-INFRA-P ROINFA 01/2006) by SEM analysis. Graphical abstract was made using BioRender.