Talasteroid, a new withanolide from the marine-derived fungus Talaromyces stollii

Abstract

A new withanolide, talasteroid (1), and a known steroid (2), along with eight meroterpenoids (3–10), were obtained from the rice culture of the marine-derived fungus Talaromyces stollii HBU-115. The structure of 1 including its absolute configuration was determined by extensive 1 D and 2 D NMR spectroscopy, and single-crystal X-ray diffraction analysis. Compound 1 represents the first withanolide featuring a 4-substituted 2,3-dimethyl-2-butenolide ring in the side chain. The isolated compounds were evaluated for their antimicrobial and antioxidant activities.

Graphic Abstract

Keywords:

• Marine-derived fungus
• Talaromyces stollii
• withanolide
• meroterpenoid
• X-ray diffraction analysis

Acknowledgments

The authors would like to thank the High Performance Computer Center of Hebei University for providing computational service.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was funded by National Natural Science Foundation of China (No. 41830535); Shandong Provincial Natural Science Foundation (Major Basic Research Projects) (ZR2019ZD18); the Program of Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao, China) Directed by Kai-Xian Chen and Yue-Wei Guo; and the Taishan Scholars Program, China.