Furanone, morpholinone and tetrahydrofuran derivatives from the marine-derived fungus Talaromyces sp. PSU-MF07

Abstract

Three new compounds including one furanone, one morpholinone and one tetrahydrofuran together with three known compounds were isolated from the broth extract of the marine-derived fungus Talaromyces sp. PSU-MF07. The structures of the isolated compounds were determined on the basis of spectroscopic methods. The relative configuration was assigned using NOEDIFF data whereas the absolute configurations were established by Mosher’s method, specific rotations and electronic circular dichroism (ECD) data. Some isolated compounds were tested for antimicrobial activity. Only known penioxalicin exhibited weak antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 with an MIC value of 200 µg/mL.

Keywords:

• Talaromyces sp
• marine-derived fungus
• furanone
• morpholinone
• tetrahydrofuran
• antibacterial activity

Acknowledgments

V.R. thanks the NSTDA Chair Professor grant (the Fourth Grant) of the Crown Property Bureau and the National Science and Technology Development Agency. S.N. acknowledges the NSTDA Chair Professor grant for a scholarship and to the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Ministry of Higher Education, Science, Research and Innovation, Thailand, the Graduate School and Faculty of Science, Prince of Songkla University for partial support.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the NSTDA Chair Professor grant (the Fourth Grant) of the Crown Property Bureau.