Abstract
Phytochemical investigation of Marsypopetalum modestum (Annonaceae) led to the isolation of a new phenylpropanoid glycoside, lyciumphenylpropanoid B (10), along with nine known compounds (1-9) from an aqueous methanolic extract of the stem. Most compounds are reported from this genus for the first time. The structures of the isolated compounds were elucidated using spectroscopic methods including NMR spectroscopy, high-resolution mass spectrometry, and quantum chemical electronic circular dichroism (ECD) calculations. Cytotoxic and antitubercular activities of several isolated compounds were evaluated. Dipyrithione (1) displayed anti-mycobacterial (MIC = 0.23 μM) and cytotoxic (IC50 = 0.8 μM in Hep G2 cells; 4.1 μM in HCT 116 cells) activities. Kelampayoside A (8) showed moderate cytotoxic activity against cancer cells.
Graphical Abstract
Acknowledgements
The authors would like to acknowledge Dr. Bethany Elkington and Dr. Mouachanh Xayveu for providing ethnomedical information and the plant material, as well as Dr. Benjamin Ramirez for assistance in recording part of the NMR spectra. Dr. Brian Guo and Dr. Junfei Zhou are thanked for assisting with designing isolation and structure elucidation strategies. Image of M. modestum is reprinted from Elkington et al. Citation2014, with permission from Elsevier.
Disclosure statement
No potential conflict of interest was reported by the authors.