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Natural Product Research
Formerly Natural Product Letters
Volume 37, 2023 - Issue 10
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Research Articles

Two new cytotoxic tetralin derivatives from Panicum turgidum

Ahmed A. Zakia Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt;b Department of Pharmacognosy, Faculty of Pharmacy, Horus University-Egypt, New Damietta, EgyptCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-5462-6971
ORCID Icon,
Yasser A. El-Amierc Botany Department, Ecology, Faculty of Science, Mansoura University, Mansoura, Egypt
&
Ahmed Ashoura Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt;b Department of Pharmacognosy, Faculty of Pharmacy, Horus University-Egypt, New Damietta, EgyptCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-4081-0369
ORCID Icon
Pages 1595-1600 | Received 20 Jan 2022, Accepted 09 Jul 2022, Published online: 22 Jul 2022
 
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Abstract

Two new tetralin compounds were isolated from the aerial parts of Panicum turgidum Forssk. Their structures were elucidated by comprehensive 1 D and 2 D NMR experiments as well as high resolution ESI mass spectrometry. In addition, these two compounds have been tested for in vitro cytotoxicity against SKOV3 (Ovarian Carcinoma) and BT-549 (Breast Carcinoma). Compound 1 showed good cytotoxic activities against SKOV3 and BT 549 with IC50 value of 5.65 ± 0.31 and 10.3 ± 0.56 µg/mL, respectively

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

The author(s) reported there is no funding associated with the work featured in this article.

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