Two new glycosides from Stachys geobombycis C.Y.Wu

Abstract

Two new compounds geobomlin A (1) and geobomlin B (2) were isolated from the roots of Stachys geobombycis C. Y. Wu. Structural determinations were established principally by two-dimensional NMR and MS data analyses. Geobomlin B showed moderate inhibitory activity against α-glucosidase with IC₅₀ = 248.77 μM. We have also determined the mechanism by which geobomlin B elicit its inhibitory effect on α-glucosidase, for which we have established a competitive inhibition mode. Docking studies confirmed our results on geobomlin B α-glucosidase inhibitory properties.

Graphical Abstract

Keywords:

• C. Y. Wu
• α-glucosidase
• glycosides
• Stachys geobombycis

Supplementary material

Supplementary material relating to this article is available online, alongside with Figures S1–S21 and Table S1.

Acknowledgement

We are grateful to Guangxi Normal University for measuring the UV, MS and NMR spectra.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Natural Science Foundation of Guangxi Province (No. 2018GXNSFBA281032) and the National Natural Science Foundation of China (No. 81860621).