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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 1
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Research Articles

7-Methoxy-13-dehydroxypaxilline: New indole diterpenoid from an endophytic fungus Penicillium sp. Nb 19

Jing Yua Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, ChinaORCID Iconhttps://orcid.org/0000-0001-7997-5967View further author information
ORCID Icon,
Jia-Peng Wangb Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical, College of Pharmacy, Dali University, Yunnan Dali, ChinaView further author information
,
Shi-Fang Liua Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, ChinaView further author information
,
Cui-Yun Yina Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, ChinaView further author information
,
De-Ying Tanga Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, ChinaView further author information
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Yi-Hang Lia Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Li-Xia Zhanga Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, ChinaView further author information
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Pages 103-111 | Received 27 Jan 2022, Accepted 26 Jul 2022, Published online: 05 Aug 2022
 
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ABSTACT

A chemical investigation of the endophyte Penicillium sp. Nb 19, isolated from leaves of the traditionally medical plant Baphicacanthus cusia (Nees) Bremek., yielded one new indole diterpenoid, 7-methoxy-13-dehydroxypaxilline (1) together with seven known metabolites (2-8). The obtained structure of compound 1 was elucidated by its spectroscopic data. In addition, the absolute configuration of compound 6 was confirmed by ECD for the first time. Compounds 1-6 were evaluated for antitumor activity against MCF-7, HepG2, and HCCC-9810 cell lines.

GRAPHICAL ABSTRACT

Disclosure statement

The authors declare that there is no conflict of interest in this paper.

Additional information

Funding

The work was supported by The Science and Technology talents and platform plan of Yunnan Province (No. 202105AG070011), Yunnan provincial Science and Technology Major Projects (No. 202102AA100020).

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