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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 1
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Research Articles

Placoisoflavones A and B, two new cytotoxic isoflavonoids from Placolobium vietnamense N.D.Khôi & Yakovlev

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Pages 112-118 | Received 04 Apr 2022, Accepted 28 Jul 2022, Published online: 09 Aug 2022
 

Abstract

Two previously unreported isoflavonoids, placoisoflavones A and B (1 and 2), along with five known compounds, calopogonium isoflavone B (3), jamaicin (4), 6-methoxycalopogonium isoflavone A (5), vestitol (6), and caviunin (7) have been isolated from the stems of Placolobium vietnamense N.D.Khôi & Yakovlev. The structures of all isolated compounds were fully characterized using spectroscopic data and comparison with the previous literature. The cytotoxicity of all isolated compounds was evaluated against HepG2 cell line, and compound 1 showed the most potent cytotoxicity with an IC50 value of 8.0 μM.

Graphical Abstract

Funding

This study was funded by Sai Gon University (TĐ2021-21).

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

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