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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 2
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Research Articles

Two new terpenoid glycosides from Isodon macrocalyx

Xiaoqin Lianga State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, ChinaView further author information
,
Yanling Changa State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, ChinaView further author information
,
Xinlan Guanb Peoples' Hospital of Pubei, Pubei, ChinaView further author information
,
Yan Huanga State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, ChinaView further author information
,
Liwei Pana State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, ChinaView further author information
,
Jun Lia State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Jian Lib Peoples' Hospital of Pubei, Pubei, ChinaCorrespondence[email protected] [email protected]
View further author information
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Pages 220-226 | Received 09 Jun 2022, Accepted 13 Aug 2022, Published online: 19 Aug 2022
 
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Abstract

One previously undescribed tricyclo-diterpenoid saponin (1), one undescribed dammarane triterpenoid saponin (2) and four known triterpenoids (3–6) were isolated from the aerial part of Isodon macrocalyx. Their structures were determined using 1 D- and 2 D-NMR, HRESIMS, and comparison of their spectroscopic data with previously reported data. The isolates were evaluated for their anti-HBV activity in vitro using the HBV transfected Hep G2.2.15 cell line. Compounds 2 and 3 exhibited moderate anti-HBV activity.

GRAPHICAL ABSTRACT

Disclosure statement

The authors declare no competing financial interest.

Additional information

Funding

One of the authors (JL.) acknowledges the following grants for funding this project: National Natural Science Foundation of China (32060097); The Natural Science Foundation of Guangxi Province (2018GXNSFDA050007).

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