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Abstract
Four new norceanothane-type triterpenes, cyclopalin A-D (1-4), and sixteen known compounds (5-20) were obtained from the fruits of Cyclocarya paliurus. Their structures were determined by spectroscopic data, experimental electronic circular dichroism (ECD) and X-ray single crystal analyses. All isolated compounds were assayed for their anti-HIV-1IIIB activity. Compound 18 exhibited potent anti-HIV-1IIIB activity with an EC50 value of 1.32 μM (SI = 151.52).
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This project was financially supported by NSFC (21762048,21967020, U1702286, 82060670), the open fund from Guangdong Key Laboratory for Innovative Development and Utilization of Forest plant germplasm, the grants of Yunnan Applicative and Basic Research Program (2018FA048, 2018FY001, P0120150150), the Program for Changjiang Scholars and Innovative Research Team in University (IRT_17R94) and project of Innovative Research Team of Yunnan Province (202005AE160005) and the project of Yunling Scholar of Yunnan Province to Weilie Xiao, Fund of Academician Working Station of Yunnan Province (2018IC057), and Yunnan Key Research and Development Program (202103AC100005). In addition, we acknowledge Meng-Di Ma and Liu-Meng Yang for their contribution of activity test and data analysis to this paper.