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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 3
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Research Article

Two new lactam derivatives from a Sphagneticola trilobata derived fungus Penicillium rubens PQJ-2

Wen-xing Lia Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of ChinaView further author information
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Xiu-qiao Zhoua Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of ChinaView further author information
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Shao-dong Jia Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of ChinaView further author information
,
Yi-nuo Wanga Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of ChinaView further author information
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Zhen-fan Sunc Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational University of Science and Technology, Haikou, People’s Republic of ChinaCorrespondence[email protected]
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Zi-yi Huanga Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of ChinaView further author information
,
Zi-ming Zhoua Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of ChinaView further author information
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Yang Huia Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of ChinaCorrespondence[email protected]
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&
Wen-hao Chena Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of China;b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, People’s Republic of ChinaCorrespondence[email protected]
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Pages 372-378 | Received 28 May 2022, Accepted 04 Sep 2022, Published online: 16 Sep 2022
 
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Abstract

A new bicyclic lactam derivatives penicilactam B (1) and a new monocyclic amide penicillamide D (2), along with four known compounds (3-6), were isolated from the fermentation broth of the derived fungus Penicillium rubens PQJ-2. Their structures and stereochemistry were elucidated by comprehensive spectroscopic analyses and quantum ECD calculations. All the compounds were evaluated for their antibacterial activities against Staphylococcus aureus subsp, Candida albicans, Escherichia coli and insecticidal activity against Helicoverpa armigera Hubner. Compounds 1-3 exhibited modest insecticidal activity against H. armigera Hubner.

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (22167013), the Key Project of Research and Development of Hainan Province (ZDYF2021SHFZ221), the Education Department of Hainan Province (Hnky2021ZD-10), the Natural Science Foundation of Hainan Province (221RC541), and the Specific Research Fund of The Innovation Platform for Academicians of Hainan Province (YSPTZX202030). Innovation Training Program for College Students (hscx2022-36).

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