Abstract
Two new resin glycosides, muricatins XII (1) and XIII (2), were isolated from the crude resin glycoside fraction of the seeds of Ipomoea muricata (L.) Jacq. (Convolvulaceae), along with three known ones, muricatins V (3), VI (4), and IX (5). Compounds 1 and 2 contained new glycosidic acids, muricatic acids E (1a) and F (2a), respectively. The structures of these compounds were determined using data obtained from spectroscopy measurements and chemical evidence. The results suggested that 1 and 2 have macrolactone structures (jalapins). Furthermore, the cytotoxic activity of the crude resin glycoside fraction and 3–5 against HL-60 human promyelocytic leukaemia cells was evaluated. All tested samples demonstrated cytotoxic activities.
Acknowledgments
We express our appreciation to Mr. H. Harazono of Fukuoka University for the measurement of the FAB-MS and ESI-TOF-MS. A part of this work was supported by Research and Study Project of Tokai University General Research Organisation (Kanagawa, Japan).
Disclosure statement
No potential conflict of interest was reported by the authors.