Compounds with antibacterial and antioxidant activities from Cadia purpurea

Abstract

Five compounds 1-5 were reported from leaves and roots of Cadia purpurea herein. 2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-17-(1-hydroxypent-4-en-2-yl)-10,13-dimethyl-1H-cyclopenta[a]phenanthren-3-ol (1), apigenin-7-O-rhaminoglucoside (2) and 13-O-pyrrolecarboxyl lupanine (3) were isolated from chloroform and methanol leaves extracts. And 5-((trihydro-2-oxy-4-(hydroxymethyl)-5-(3-hydroxyphenyl)furan-3yl)methyl)benzene-1,2,3,4-tetraol (4) and bis(2-hydroxybutyl) phthalate (5) were isolated from the chloroform: methanol (1:1) roots extract. The structures of the compounds were characterized using NMR, IR and GC/MS spectroscopic data. In vitro antibacterial and antioxidant activities of leaves extracts and compounds 1, 2, 4, and 5 were also evaluated. The present findings disclosed that tested compound isolates and extracts showed dose-dependent antibacterial and antioxidant activities. The molecular docking result indicates that isolated compounds show no violation of the Lipinski’s rule of five. Compounds 1, 2, 4, and 5 were reported herein for the first time from the leaves and roots of C. purpurea. Further biochemical investigation on whole parts of the plant may uncover additional chemical entities with better biological activities.

Graphical Abstract

Keywords:

• Cadia purpurea
• antioxidant activity
• antibacterial activity
• compound isolates
• molecular docking

Acknowledgements

This work was supported by Adama Science and Technology University under Grant (ASTU/AS-R/003/2020); and the World Academy of Sciences (TWAS) and the United Nations Educational, Scientific and Cultural Organization (UNESCO) under the TWAS Research Grant (RGA No. 20-274 RG/CHE/AF/AC_G – FR3240314163).

Supplementary material

Spectroscopic and molecular docking data is available online.

Conflict of interest

None.