Three new rotenoids from the stems of Derris elliptica and their anti-microbial activity

Abstract

Three new rotenoids, named derieliptosides A-C (1–3), were isolated from the stems of Derris elliptica (Wall.) Benth. Their structures were determined by HR-ESI-MS and NMR spectroscopic methods. Absolute configurations of them were elucidated by analysis of ECD spectra in comparison with TD-DFT calculation. Compounds 1–3 inhibited the growth of fungus Candida albicans and selectively inhibited bacterial strains. Of these, compound 1 showed selective inhibition on the growth of Enterococcus faecalis (MIC: 37.5 µM and IC₅₀: 10.6 µM), Staphylococcus aureus (MIC: 75 µM and IC₅₀: 22.7 µM), and C. albicans (MIC: 37.5 µM and IC₅₀: 11.2 µM).

Graphical Abstract

Keywords:

• Derris elliptica
• derieliptoside
• rotenoid
• absolute configuration
• anti-microbial activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research is funded by Graduate University of Science and Technology under grant number GUST.STS.ĐT2020-HH12.