Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 7
Submit an article Journal homepage
132
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Three new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Chengyao Maa Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China;b Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, ChinaORCID Iconhttps://orcid.org/0000-0002-5160-5347View further author information
ORCID Icon,
Yue Lib Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, ChinaView further author information
,
Jiahui Lub Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, ChinaView further author information
,
Maolin Wangb Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, ChinaView further author information
,
Xiang Lib Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, ChinaCorrespondence[email protected]
View further author information
,
Jianwei Chenb Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, ChinaView further author information
,
Yong Chenb Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, ChinaView further author information
&
Wenzheng Jua Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaCorrespondence[email protected]
View further author information
 show all
Pages 1135-1139 | Received 05 Aug 2022, Accepted 30 Sep 2022, Published online: 19 Oct 2022
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Three new annonaceous acetogenins, annotemoyin L (1), annotemoyin Y (2) and annotemoyin X, (3) were isolated from the seeds of Annona squamosa Linn. Their structures were ascertained by chemical methods and spectral data. The cytotoxic activities of compounds against three multidrug-resistant cancer cell lines were evaluated, and compound 3 exerted strong cytotoxicity against SMMC 7721/ADR (IC50 0.163 μM), A549/T (IC50 0.064 μM) and MCF-7/ADR (IC50 0.057 μM).

Graphical Abstract

Acknowledgements

This work was supported by the National Natural Science Foundation of China (grant number 81573577, 82104355 and 81403082) and China Postdoctoral Science Foundation (2021M701766).

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (grant number 81573577, 82104355 and 81403082) and China Postdoctoral Science Foundation (2021M701766).

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 861.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.