Chemical components and monoamine oxidase B inhibition activities from the tubers of Sauromatum giganteum (Engl.) Cusimano & Hett

Abstract

The rhizome tuber of Sauromatum giganteum is known as 'Bai Fuzi’ in China and has been ethnomedicinally used to treat various neurological diseases. It is considered to possess anti-Parkinson’s disease (PD) potential, but the active compounds responsible for that is still unclear. In this work, nineteen compounds were isolated and identified from rhizome tuber of this plant, among which four were firstly reported, i.e. berberine (1), nicotinamide (2), rutin (3) and 5-caffeoylquinic acid (4). Six compounds (1, 3, 4, 8, 14 and 15) exhibited moderate inhibitory activity against MAO-B with IC₅₀ of 118.8, 45.6, 96.2, 65.8, 40.0, and 49.8 µM, and two compounds (3 and 4) displayed significant protective effect on 6-OHDA-induced PC-12 cell model. The molecular docking of the bioactive compounds and MAO-B was carried out to explore the binding mode. The findings revealed the potential of S. giganteum as anti-PD herb and its inclusion in TCM could be explored.

Graphical Abstract

Keywords:

• Sauromatum giganteum
• Parkinson’s disease
• phytochemicals
• monoamine oxidase
• molecular docking

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was funded by the Science and Technology Service Network Initiative of the Chinese Academy of Sciences (No. ZSTH-007). We are grateful to the CAS-TWAS President’s Fellowship for student sponsorship.