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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 8
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Research Articles

Secondary metabolites isolated from Penicillium christenseniae SD.84 and their antimicrobial resistance effects

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Pages 1311-1319 | Received 19 Jul 2022, Accepted 15 Oct 2022, Published online: 06 Nov 2022
 

Abstract

A pair of new quinolone alkaloid enantiomers, (Ra)-(-)-viridicatol (1) and (Sa)-(+)-viridicatol (4), and seven known compounds, namely, 2, 3 and 59, were isolated from Penicillium christenseniae SD.84. The structures of 1 and 4 were determined using NMR and HRESIMS data. Theoretical calculations through CD and ECD confirmed 1 and 4 as a pair of enantiomers. The MIC values of 4 against Staphylococcus aureus and methicillin-resistant S. aureus were 12.4 and 24.7 μM, respectively, compound 1 had no inhibitory activity. Antimicrobial assays of 2, 3, and 57 showed a moderate activity against S. aureus and methicillin-resistant S. aureus. This study demonstrated the remarkable potential of Penicillium sp. to produce new drug-resistant leading compounds, thereby advancing the mining for new sources of antimicrobial agents.

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Disclosure statement

The authors declare no potential conflicts of interest.

Additional information

Funding

National Natural Science Foundation of China (Nos.31770024), Innovation and Development Joint Fund of Natural Science Foundation from Shandong Province (ZR2021LSW022), Exploration Innovation Team (2021GXRC062), Young Taishan Scholarship to Xuekui Xia (tsqn202103100), Natural Science Foundation from Shandong Province (ZR2021QB173), Highend Foreign Experts Recruitment Program (G2021023002L), Key innovation Project of Qilu University of Technology (Shandong Academy of Sciences) (2022JBZ01-06).

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